个人简介/Profile
四川天府峨眉计划创业领军人才、四川农业大学校学术委员会委员、中国农业生物化学与分子生物学学会副秘书长、四川省科技青年联合会常务理事、四川省植物病理学会理事，长期从事植物小肽信号机理及其应用研究和人才培养工作。2010年于香港中文大学获得博士学位，2011-2014年分别于香港中文大学与哈佛医学院从事博士后研究，2014年进入四川农业大学从事教学科研工作。从事科研工作以来，先后主持国家人力资源和社会保障部高层次留学人才回国工作资助（该年度四川省唯一获得人选）、霍英东基金会青年教师基金、四川省杰出青年基金等省部级项目7项，主研获教育部自然科学奖二等奖1项。在Plant Cell、Trends in Plant Science、Plant Journal、Plant Physiology、Journal of Experimental Botany等国内外学术期刊发表论文30余篇。
Academic Committee Member of Sichuan Agricultural University, deputy Secretary-General of the Chinese Society of Agricultural Biochemistry and Molecular Biology, standing member of the Sichuan Science and Technology Youth Federation, member of the Sichuan Plant Pathological Society, Sichuan Province "Tianfu Emei Plan entrepreneurial Leaders". Engaged in developing efficient and safe targeted peptide pesticides, establishing a green control theory and application system for plant diseases with peptides at the core, aiming to reduce the use of chemical pesticides, ensure food security, protect life health, and maintain ecological balance.
研究方向/Research Interests
植物小肽的研与利究用
Peptide biology
研究内容/Research Contents
1. 植物小肽信号的发掘及其信号转导机制
2. 小肽类生物农药的创制
1. Creation of targeted peptide pesticides
2. Signal transduction of peptides in plants
招生专业/Enrollment Major
【博士】071010生物化学与分子生物学
【学硕】071010生物化学与分子生物学
【专硕】086000生物与医药
Email：yicai@sicau.edu.cn
【Doctoral】:071010 Biochemistry and molecular biology
【Academic Master】:071010 Biochemistry and molecular biology
【Professional Master】:086000 Biology and Medicine
教育背景/Education
1998-2002年，南开大学微生物学专业，学士学位
2002-2005年，南开大学微生物学专业，硕士学位
2006-2010年，香港中文大学生物学专业，博士学位
1998-2002，Nan Kai University，Department of Microbiology，B.S
2002-2005，Nan Kai University，Department of Microbiology，M.S
2006-2010，The Chinese University of Hong Kong， Department of Biology，Ph.D
工作经历/Working Experience (Full-time)
2010-2013，香港中文大学，生命科学学院，助力研究员
2013-2014，哈佛医学院，遗传学系，博士后
2014-至今，四川农业大学生命科学学院，教授
2010-2013，The Chinese University of Hong Kong，School of Life Sciences，Research Associate
2013-2014，Harvard Medical School，Department of Genetics，Research Fellow
2014-present，Sichuan Agricultural University，Department of Bioengineering，Professor
主要社会兼职/Social Part-time
2018.4至今，四川省青年科技联合会 常务理事
2018.5至今，四川省植物病理学协会 理事
2023.8至今，中国农业生物化学协会 副秘书长
2017-present，Academic Committee Member of Sichuan Agricultural University
2018-present，Standing member of the Sichuan Science and Technology Youth Federation
2018-present，Member of the Sichuan Plant Pathological Society
2018-2023，Director of Youth Committee of Chinese Society of Agricultural Biochemistry and Molecular Biology
2023-present，Deputy Secretary-General of the Chinese Society of Agricultural Biochemistry and Molecular Biology
主要科研奖励和个人荣誉/Awards and Honors
2018，获教育部自然科学奖二等奖（7/7）
2021，入选四川天府峨眉计划创业领军人才
2021，Selected as one of Sichuan Province "Tianfu Emei Plan entrepreneurial Leaders".
2021，Selected as one of Chengdu "Rongpiao Plan entrepreneurial Leaders".
2018，Molecular regulation mechanism of selective transport and degradation of plant protein，Scientific Research Outstanding Achievement Award，Second Prize of Natural Science Award.
代表性科研项目/Representative Projects
1.校企共建“四川农业大学生命科学学院肽灵生物农药研究中心” 校企合作 2021-2026
2.重组类受体激酶增强植物抗病力 霍英东教育基金会 2016-2018
3.植物类受体激酶对抗病的功能性研究 四川省科技厅 2016-2018
4.植物发育与抗病创新团队 四川省教育厅 2016-2018
5.高层次留学人才回国工作资助 中国人力资源和社会保障部 2015-2017
1. Tailing Biopesticide Research Center, Lusyno Biotech Ltd.,￥5,000,000.2021-2026
2. Using recombinant receptors to enhance plant immunity, Young Scholars Fund, Henry Fok Foundation, ￥140,000. 2016-2018
3. Functional studies on receptor like kinases in plant immunity, Distinguished Young Scholars, Science and Technology Department of Sichuan, ￥500,000. 2016-2018
4. Plant development and defence, Innovative Research Team, Education Department of Sichuan, ￥100,000. 2016-2018
5. High Level Talent Research Fund, Ministry of Human Resources and Social Security (MOHRSS), ￥300,000. 2015-2018
6. Targeting mechanisms of cytokinin receptors, Education Department of Sichuan, ￥25,000. 2015-2017
7. Research Start-Up Fund, Sichuan Agricultural University, ￥800,000. 2014-2018
代表性学术成果/Representative Publications
1.Yu X.*, Huang Z.*, Cheng Y., Hu K., Zhou Y., Yao H., Shen J., Huang Y., Zhuang X.#, Cai Y.# (2024) Comparative genomics screens identify a novel small secretory peptide, SlSolP12, which activates both local and systemic immune response in tomatoes and exhibits broad-spectrum activity. J. Agric. Food Chem., online.
2. Li J.*, Huang Y., Yu X., Wu Q., Diao Z., Man X., You H., Shen J., Cai Y.# (2024) Screening and application of CLE peptides for drought-resistance in Solanaceae crops. J. Agric. Food Chem., 72, 13869–13884
3.Diao Z.*, Yang R.*, Wang Y., Cui J., Li J., Wu Q., Zhang Y., Yu X., Gong B., Huang Y., Yu G., Yao H., Guo J., Zhang H., Shen J., Gust A., Cai Y.# (2024) Functional screening of the Arabidopsis 2C protein phosphatases family identifies PP2C15 as a negative regulator of plant immunity by targeting BRI1-associated receptor kinase 1, Mol. Plant Pathol., 25:e13447.
4.Yu X.*, Wang H., Lei F., Li R., Yao H., Shen J., Ain N., Cai Y.# (2023) Structure and functional divergence of PIP peptide family revealed by functional studies on PIP1 and PIP2 in Arabidopsis thaliana. Front. Plant Sci., 14:1208549.
5.Huang Y.*, Cui J.*, Li M.*, Yang R., Hu Y., Yu X., Chen Y., Wu Q., Yao H., Yu G., Guo J., Zhang H., Wu S.#, Cai Y.# (2023) Conservation and divergence of flg22, pep1 and nlp20 in activation of immune response and inhibition of root development. Plant Sci., 331:111686.
6.Huang Y.*#, Li J.*, Huang T.*, Bai X., Li Q., Gong Y., Hoy R., He Z., Liu J., Liao J., Yuan M., Ding C., Li X., Cai Y.# (2023) The homeostasis of R protein RPS2 is regulated negatively by the RING-type E3 ligase MUSE16. J. Exp. Bot., 74:2160-2172.
完整文章列表：https://www.researchgate.net/profile/Yi-Cai-48
科研团队简介/Research Group
本人为“小肽农药分子设计与作用机制”团队负责人，团队成员4人。团队以国家“两减”战略为导向，开发高效安全具备不同功能的靶向小肽农药，建立以小肽为核心的植物病虫害绿色防控理论和应用体系，以期降低化学农药的使用量，保障粮食安全、生命健康和生态平衡。本研究组利用计算生物学、分子生物学、组学以及合成生物学技术围绕以下两个方向开展研究：一、调控植物抗病、抗逆和发育的小肽信号挖掘及机理阐释。二、新型小肽类生物农药的研制。团队研究成果发表于J. Exp. Bot.，J. Agric. Food Chem.，Mol. Plant Pathol.等期刊。团队主持国家自然科学基金项目3项、霍英东教育基金会青年教师基金1项、四川省杰出青年基金等省部级科研项目10余项，申请中美发明专利6项，并初步实现成果转化。课题组常年招聘科研助理、博士后、青年研究员和青年教师，欢迎具有计算生物学、合成生物学、分子生物学、植物保护等专业背景的硕博士研究生和博士后联系。
In alignment with the national "two reductions" strategy, our research team is dedicated to the development of multifunctional, efficient, and safe targeted small peptide pesticides. We are committed to constructing a comprehensive green prevention and control framework for plant diseases, centered on small peptides, with the ultimate goal of diminishing the reliance on chemical pesticides. Our efforts are geared towards safeguarding food security, preserving life health, and maintaining ecological equilibrium.Utilizing an interdisciplinary approach, our research group integrates computational biology, molecular biology, omics technologies, and synthetic biology to advance our investigative pursuits in two primary domains: （1）Discovery and Mechanistic Elucidation of Small Peptide Signals;（2）Development of Novel Peptide Biopesticides. Our scholarly contributions have been recognized through publications in esteemed journals such as J. Exp. Bot., J. Agric. Food Chem., Mol. Plant Pathol.. The team has successfully managed over 10 provincial and ministerial-level scientific research projects, including three projects funded by the National Natural Science Foundation, the Young Teachers Fund from the Henry Fok Education Foundation, and the Sichuan Outstanding Youth Fund. Furthermore, we have filed for six invention patents in both China and the United States, marking a significant step towards the commercialization and practical application of our research outcomes.
教学情况/Teaching Courses
现授“基因工程”（本科）
1.Genetic engineering（Undergraduate student）
2.Advances in plant science（Graduate student）
