个人简介
目前主持四川省自然科学基金项目1项，以第一或责任作者在Aquaculture、Developmental and comparative immunology、Fish and shellfish immunology等国内外学术期刊发表论文10余篇。
研究方向
1.水生生物免疫学
2.水产动物代谢调控与环境健康
研究内容
1.鱼Toll样受体信号转导途径及调节网络
2.高温胁迫下冷水鱼类肝脏代谢响应机制
教育背景
2010-2014年，四川农业大学药物制剂专业，学士学位
2014-2017年，四川农业大学生物物理学专业，硕士学位
2017-2022年，四川农业大学生物物理学专业，博士学位
2019-2021年，比利时根特大学VIB生物医学技术研究中心，博士联合培养
工作经历
2022年至今，四川农业大学，生命科学学院，讲师
代表性科研项目
1.鱼类特有TLR25单独及与IRF1协同调控信号通路的机制研究，四川省自然科学基金青年项目，2023-2024
2.齐口裂腹鱼TLR25/MyD88信号通过增加IRF1蛋白稳定性促进IFNa基因表达的机制研究，中国博士后基金项目，2024-2025
代表性学术成果
1. Yunkun Li*, Shihui Yi, Wuhao Tang, Lei Shi, Huizhen Yan, Lei Ning, Jing Pu, Kanbei Shiyi, Lanxin Zhang, Xiaoshuang Chen, Jiayun Wu, Shiyong Yang, Xianyin Zeng, Xiaogang Du. Teleost-specific TLR25/MyD88 signaling promotes K63-linked ubiquitination of IRF1 to induce IFNa gene expression. Fish Shellfish Immunology, 2025, 166:1 10672.
2. Yunkun Li, Bangzhuo Huang, Shijie Sun, Nanyi Liu, Yunqi Li, Minwen Lan, Xiaoai Wang, Yuanwei Zhang, Anli Wu, Shiyong Yang, Jiayun Wu, Xianyin Zeng, Xiaofu Pan, Xiaogang Du*. Immunoprotection effects of chicken egg yolk immunoglobulins (IgY) against Aeromonas veronii infection in Sinocyclocheilus grahami. Aquaculture, 2023, 563: 738935.
3. Yunkun Li, Jiayu Wu, Dong Li, Anqi Huang, Guixian Bu, Fengyan Meng, Fanli Kong, Xiaohan Cao, Xingfa Han, Xiaofu Pan, Wei Fan, Shiyong Yang, Jun Wang, Xianyin Zeng, Xiaogang Du*.Teleost-specific TLR25 identified from Schizothorax prenanti may recognize bacterial/viral components and activate NF-κB and type I IFNs signaling pathways. Fish and Shellfish Immunology, 2018, 82: 361-370.
4. Yunkun Li, Puzhen Xia, Jiayu Wu, Anqi Huang, Guixian Bu, Fengyan Meng, Fanli Kong, Xiaohan Cao, Xingfa Han, Guozhi Yu, Xiaofu Pan, Shiyong Yang, Xianyin Zeng, Xiaogang Du*. The potential sensing molecules and signal cascades for protecting teleost fishes against lipopolysaccharide. Fish and Shellfish Immunology, 2019, 97: 235-247.
5. Yunkun Li, Jiabei Han, Jiayu Wu, Dong Li, Xixi Yang, Anqi Huang, Guixian Bu, Fengyan Meng, Fanli Kong, Xiaohan Cao, Xingfa Han, Xiaofu Pan, Shiyong Yang, Xianyin Zeng, Xiaogang Du*. Transcriptome-based evaluation and validation of suitable housekeeping gene for quantification real-time PCR under specific experiment condition in teleost fishes, Fish and Shellfish Immunology, 2020, 98: 218-223.
6. Yunkun Li, Jiayu Wu, Dong Li, Anqi Huang, Guixian Bu, Fengyan Meng, Fanli Kong, Xiaohan Cao, Xingfa Han, Xiaofu Pan, Wei Fan, Shiyong Yang, Xianyin Zeng, Xiaogang Du*. Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophilainfection in Schizothorax prenanti. Fish and Shellfish Immunology, 2018, 84: 816-824.
7. Yunkun Li, Jiayu Wu, Dong Li, Anqi Huang, Guixian Bu, Fengyan Meng, Fanli Kong, Xiaohan Cao, Xingfa Han, Xiaofu Pan, Wei Fan, Shiyong Yang, Xianyin Zeng, Xiaogang Du*.Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti. Fish and Shellfish Immunology, 2018, 84: 816-824.
科研团队简介
水产动物养殖受到温度、水体致病微生物等多种环境因素的影响，研究环境因素对鱼类养殖健康的影响及鱼类适应性调节机制对提高养殖效益至关重要。本研究团队聚焦鱼类耐高温的代谢响应机制及环境-免疫的互作机制，采用生物信息学、组织病理学、分子生物学等相关实验技术，开展（1）鲟鱼代谢响应高温环境的机制和（2）鱼类免疫分子介导环境-免疫互作的信号调节网络研究，为解决养殖健康问题和培育优质品种提供理论参考。
教学情况
现授“酶工程与技术”“基础生物化学”（本科）
