个人简介/Profile
2024年4月毕业于荷兰瓦赫宁根大学，获分子病毒学博士学位，研究方向聚焦于疫苗与抗体工程。近年来在国内外学术期刊发表或参与发表论文7篇，授权国家发明专利2项。以第一作者身份在 Nature Communications、Vaccine、Vaccines 等国际期刊发表研究成果，其中部分成果已成功应用于荷兰WBVR研究所与勃林格殷格翰公司的多项成果转化项目。
Graduated in April 2024 from Wageningen University, the Netherlands, with a Ph.D. in Molecular Virology, focusing on vaccine and antibody engineering. In recent years, published or co-authored 7 papers in domestic and international academic journals and obtained 2 granted national invention patents. As first author, published research findings in international journals including Nature Communications, Vaccine, and Vaccines. Part of this work has been successfully translated into multiple projects in collaboration with Wageningen Bioveterinary Research (WBVR) and Boehringer Ingelheim.
研究方向/Research Interests
动物生殖与代谢相关的新型疫苗创制与效力优化体系构建，疫苗质量控制与效力评价标准化平台建设，以推动新一代疫苗创制与落地转化。
Focusing on the development of novel vaccines targeting animal reproduction and metabolism, coupled with the establishment of efficacy-enhancing platforms and standardized systems for vaccine quality control and potency assessment, to advance next-generation vaccine innovation and translation.
研究内容/Research Contents
1.基于人工智能的新型生物疫苗设计
2.疫苗佐剂与递送体系的研发与优化
3.疫苗长效化的免疫机制的系统研究
4.疫苗质控与效力评价标准化体系建立
1.AI-driven design of next-generation biovaccines
2.Development and optimization of novel adjuvants and delivery systems
3.Systems-level investigation of the mechanisms underlying durable vaccine-induced immunity
4.Establishment and standardization of platforms for vaccine quality control and potency evaluation
招生专业/Enrollment Major
【学硕】: 071009细胞生物学
【专硕】: 086000生物与医药
Email：haozhouli@sicau.edu.cn
【Academic Master】: 071009 Cell Biology
【Professional Master】:086000 Biology and Medicine
教育背景/Education
2010.09-2014.06 四川农业大学，小动物医学，学士学位
2015.09-2018.06 四川农业大学，临床兽医学，硕士学位
2018.09-2024.04 荷兰瓦赫宁根大学，分子病毒学，博士学位
2010.09-2014.06 B.Sc. in Small Animal Medicine, Sichuan Agricultural University,
2015.09-2018.06 M.Sc. in Clinical Veterinary Medicine, Sichuan Agricultural University,
2015.09-2018.06 Ph.D. in Molecular Virology, Wageningen University, the Netherlands
工作经历/Working Experience (Full-time)
2025.05至今，四川农业大学，生命科学学院，特聘副教授
2025.05 to date, Sichuan Agricultural University, College of Life Sciences, Associate Professor
代表性科研项目/Representative Projects
1.荷兰农业、自然和食品质量部项目Vesiculaire ziekten en leukose (WOT-01-002-034)，主研
2.四川农业大学引进人才科研启动经费，15万元，主持
1.Project “Vesiculaire ziekten en leukose” (WOT-01-002-034) funded by the Dutch Ministry of Agriculture, Nature and Food Quality, key researcher.
2.Scientific Research Start-up Fund for Introduced Talent, Sichuan Agricultural University, CNY 150,000, principal investigator.
代表性学术成果/Representative Publications
1. Li, H., Liu, P., Dong, H., Dekker, A., Harmsen, M. M., Guo, H., Wang, X., & Sun, S. (2024). Foot-and-mouth disease virus antigenic landscape and reduced immunogenicity elucidated in atomic detail. Nature communications, 15(1), 8774. 一作，中科院大类1区Top，IF-2024=16.6
2. Li, H., Dekker, A., Sun, S., Burman, A., Kortekaas, J., & Harmsen, M. M. (2021). Novel Capsid-Specific Single-Domain Antibodies with Broad Foot-and-Mouth Disease Strain Recognition Reveal Differences in Antigenicity of Virions, Empty Capsids, and Virus-Like Particles. Vaccines, 9(6), 620. 一作，IF-2024=7.8
3. Li, H., Dekker, A., Zhang, Y., Zhang, Y., Harmsen, M., van der Poel, W., Guo, H., & Sun, S. (2025). Novel liquid-phase blocking ELISA using single-domain antibody M8 and virus-like particles for in-vitro potency assessment of foot-and-mouth disease virus-like particle vaccine. Vaccine, 62, 127466. 一作，IF-2024=4.5
4. Harmsen, M. M., Li, H., Sun, S., van der Poel, W. H. M., & Dekker, A. (2023). Mapping of foot-and-mouth disease virus antigenic sites recognized by single-domain antibodies reveals different 146S particle specific sites and particle flexibility. Frontiers in veterinary science, 9, 1040802. 二作，IF-2024=2.9
科研团队简介/Research Group
动物生殖性能调控及新型疫苗创制团队由1名教授、3名副教授和1名讲师组成。团队紧密围绕生殖-代谢-免疫系统的诸多激素，研发动物生殖/代谢调控新技术和新型高效生殖/代谢调控疫苗，着力攻克影响生殖/代谢调控疫苗高效、高成本及免疫逃逸等问题后面的理论和技术瓶颈性难题，为推动我国畜牧业高质量发展奠定理论基础和提供技术支撑。
The Animal Reproductive Performance Regulation and Novel Vaccine Development Team consists of one professor, three associate professors, and one lecturer. The team focuses closely on multiple hormones of the reproductive–metabolic–immune systems, developing new technologies and innovative, efficient vaccines for reproductive and metabolic regulation in animals. Their work aims to overcome theoretical and technical bottlenecks behind challenges such as improving efficacy, reducing costs, and addressing immune evasion in reproductive/metabolic regulation vaccines, thereby laying a solid theoretical foundation and providing technical support for promoting the high-quality development of animal husbandry in China.
教学情况/Teaching Courses
